CRRT is used increasingly in Intensive care units across the world these days. The latest state of the art Gambro Prismaflex CRRT machine is being used for continuous renal replacement therapy in our hospital ICU. CRRT is a form of slow and continuous blood purification process used in patients with severe renal failure with hemodyamic instability ( low blood pressure) . As the name suggests, it is a form of continuous therapy performed for more than 24 hours and can be continued for several days. The major difference between the regular intermittenthemodialysis (IHD) and CRRT is the rate at which the water and wastes are removed from the blood. In regular hemodialysislarge amounts are removed in a short span of around 4 hours whereas in CRRT the removal takes place at a slow and steady pace because of which it is very useful in patients in low blood pressure. CRRT helps in better fluid and acid base management . This also helps in improving the hemodyamic stability of critically ill patients in an intensive care setting. This therapy is advantageous in patients requiring neurosurgical intervention as it helps in reducing the pressure within the brain.